University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

170

Pages:

1
Author:

Mariam A. A.

ANKYLOSING SPONDYLITIS Bacterial exposure Genes coding for TNFS HLA B27 misfolded B27 HHC Stiffening of inflamed invertebral joints facet joints no linked antibody TNF-α IL-17 macrophages → 1 COSTL impact of bacterial infection Collagen II, Z I, X Prolonged inflammation MHC II, αβ T cells abnormal Wnt pathway osteoclasts → collagen type I, II, X's alkaline phosphatase ↓ osteocalcin growth factors alkaline phosphatase ossification of ligaments fibroblasts replace destroyed joint with fibrous tissue ↓ fibrous bands around joints limits motion TGF-β ↓ morphogenic proteins → ossification of bones ankylosed joints immune cells sign of inflammation asymetrical oligoarthritis spinal joints inflammation on edges dull pain axial spine inflammation base of spine tilt to left loss of motion short & rigid trunk based on kyphosis immobile lumbar spine loss of flexion sacroiliac joints ↓ lumbar lordosis ↑ thoracic kyphosis inflammation on edges stiffness of spine (as ribs also affected) shortness of breath syndesmophytes synovial joints necrotic bone dull pain enthesis site of bone insertion immune cells sign of inflammation especially oligoarthritis many body locations axial spine inflammation base of spine tilt to left loss of motion short & rigid trunk based on kyphosis immobile lumbar spine loss of flexion sacroiliac joints ↓ lumbar lordosis ↑ thoracic kyphosis inflammation on edges stiffness of spine (as ribs also affected) shortness of breath syndesmophytes