University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

132

Pages:

1
Author:

Mariam A. A.

Top Left Section Pathophysiology & Pathogenesis SNS overstimulation ↑ HR, ↑ RR, ↑ BP, ↑ Sweating, ↑ Tremors, dilated pupils, ↓ digestion control When anxiety is classified by ↑ of GABAnergic neurons The remedy --> ↑ GABA benefit no longer used due to side effects short eg. midazolam long acting eg. diazepam intermediate acting eg. lorazepam, oxazepam ↑ sedation of hour long rebound effect risk of abuse most popular because safe GABA agonist bind on GABA-R ligand gated Cl channel ligand gated K channel Top Right Section Start off with Anxiolysis 4-6 wts to become Chronic Anxiolysis just for the breakthrough Pathophysiology Pathogenesis physical symptoms Benzodiazepines can cause abuse PRN SSRI or SNRI PRN Buspirone SNS hyperstimulation ↑ Cortizeram shut only when day disperse limbic system in brain GABA emotional control SNS hyperstimulation bad anxiety generalise if Pts has Pharmacology no longer used due to side effects Barbiturates Benzodiazepines short eg. midazolam long acting eg. diazepam intermediate acting eg. lorazepam, oxazepam ↑ sedation of hour long rebound effect risk of abuse most popular because safe Buspirone rebound effect takes 3-4 wks to show effect no sedation not controlled substance adjunctive to SSRI can be used alone Pharmacology no calling powerful CYPASO Adapendance + tolerances difficulty of dose dispenso drug discountuation ↑ CYP450 break drugs powerful CYP450 Bottom Left Section when anxiety is classified by ↑ of GABAnergic neurons The remedy --> ↑ GABA benefit no longer used due to side effects short eg. midazolam long acting eg. diazepam intermediate acting eg. lorazepam, oxazepam ↑ sedation of hour long rebound effect risk of abuse most popular because safe GABA agonist bind on GABA-R ligand gated Cl channel ligand gated K channel Bottom Right Section Buspirone rebound effect takes 3-4 wks to show effect no sedation not controlled substance adjunctive to SSRI can be used alone Pharmacology no calling powerful CYPASO Adapendance + tolerances difficulty of dose dispenso drug discountuation ↑ CYP450 break drugs powerful CYP450 Buspirone selective seratonin reuptake inhibitor bind on seratonin receptor 5HT1A limbic system narrow eg. escitalopram, cibelepral best for panic disorder SARI bind on subunt of GABA-R GABA appaiste eg. venlafaxine, dulocketine selectine seratonin reuptake eg. escitalopram, cibelepral