University:
Western Sydney University
Course:
MEDI 2003 | Clinical Sciences 2
Academic year:

2024
Views:

269

Pages:

1
Author:

Mariam A. A.

FRONTOTEMPORAL Degeneration of frontal & temporal lobe → Pick’s disease is a subtype MAPT cytoskeleton TAR DNA-binding protein 43 (TOP43) microtubules → move molecules across neurons tubulins held together with tau ↓ transcription regulation of the nucleus abnormal tau protein, phosphorylated out the tubulins tau aggregates tau oligomers hyperphosphorylated tau loss function changes in tau shape & solubility of axons neurodegeneration neuroinflammation neurotoxicity brain atrophy sulci get wider ventricles expand Pick bodies are only made of tau isoforms tau targets hyperphosphorylated tau loss function changes in tau shape & solubility of axons neurodegeneration neuroinflammation neurotoxicity brain atrophy sulci get wider ventricles expand in AD → neurofibrillary tangles β-amyloid & tau isoforms tau pathology hyperphosphorylated tau loss function changes in tau shape & solubility of axons neurodegeneration neuroinflammation neurotoxicity brain atrophy sulci get wider ventricles expand FTT → always neuro-degenerative