University:
York University
Course:
BIOL 2020 | Biochemistry
Academic year:

2023
Views:

192

Pages:

2
Author:

Nick T.

Monoamines Relationship between depression: Lack of these neurotransmitters Monoamine Oxidase Inhibitors Block the oxidation of monoamines Blocks removal of the signal messenger Increases concentration Phosphodiesterase Inhibitors Block hydrolysis of second messenger cAMP Increases the concentration of signaling molecules Prolongs the signal Dopamine Dopamine produces the feeling that results from a rewarding experience a "natural high" The more the dopamine receptors are stimulated the greater the high Termination of the Signal is a two step process Indirect Action must remove both the primary messenger (monoamine) and secondary messenger (cAMP) Primary messenger removed by reuptake or enzyme destruction Secondary messenger removed by enzymatic destruction Secondary messenger removed by enzymatic destruction phosphodiesterase hydrolyzes the cAMP inside the cell terminal to AMP Cocaine Blocks reuptake of dopamine from the synapse Amphetamines accelerate release of dopamine Drugs Histamine Binds to two different types of receptors H1 Receptors Found in respiratory tract Affect airway constriction H2 Receptors Found in stomach Affect HCL secretion Tricyclic Antidepressent (Elavil) Inhibits the reuptake of Seratonin + norepinephrine from the Synapse Monoamine Oxidase Inhibitor Inhibits the enzyme that destroys monoamines Selective Serotonin Reuptake Inhibitors SSRI More selective than tricyclics Inhibit only the reuptake of Seratonin Fluoxetine - an SSRI Antihistamines Counteract the effect of histamine Bind to receptor to competitively block the attachment of histamine to its receptor "histamine antagonist" All antihistamines have a tertiary ethylamine side chain Opiate drugs relieve pain 5 Naturally occurring pentapeptides that act to relieve pain