University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

490

Pages:

2
Author:

esfredint7qo

Trypanosoma Cruzi Features: 1. It is predominant in: a. Southern America b. Central America Transmission: 1. Reduviid bug a. Also called kissing bug Diseases: The disease it causes is divided into: 1. Acute Form a. Mostly asymptomatic b. Localized inflammation around biting site might be seen 2. Chronic Form a. It is also called Chagas Disease and is characterized by: i. Megacolon 1. Leads to extreme constipation ii. Dilated cardiomyopathy iii. Megaesophagus Lab Diagnosis: Lab diagnosis for acute and chronic disease is separate. Acute Infection Lab Diagnosis: 1. Blood smear a. Used to visualize motile trypanosomes b. Effective only during active infection 2. Heart Biopsy a. Trypanosomes visualized within cardiac myocytes Chronic Infection Lab Diagnosis: 1. Serology 2. Clinical symptoms Treatment: 1. Nifurtimox a. For acute infection 2. No treatment available for chronic Chagas Life Cycle: (6) Replication inside the bug (1) Reduviid bug bites and deposits infected feces in wound (2) Scratching of wound promotes infiltration of T.cruzi (trypomastigote) into the blood (5) Reduviid bug bites (4) Amastigotes transform into trypomastigote and burst into bloodstream (3)Trypomastigote gets into cells and replicates as amastigote