University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

30

Pages:

1
Author:

Accinkiquicpqw

Bordetella Pertussis (-) Transmission: 1. Respiratory droplets Pathogenesis: 1. Does not invade a. Attaches to respiratory epithelium through pilli and releases toxins 2. Pertussis Toxin a. Gi inhibition through ribosylation i. Increases cAMP ii. Disables chemokine receptors of lymphocytes 1. Leads to inability of lymphocytes to enter lymphoid tissues 2. Increase in circulating lymphocytes (LYMPHOCYTOSIS) 3. Adenylate Cyclase Toxin a. Increases cAMP 4. Tracheal toxin a. Part of peptidoglycan wall of pertussis b. Damages ciliated cells of respiratory epithelium Diseases: 1. Catarrhal Phase a. 1-2 weeks b. Lacrimation, Rhinorrhea etc 2. Paroxysmal Phase a. 2 weeks or 2 months b. Whooping cough 3. Convalescent Phase a. Up to 3 months (can be more) b. Gradual reduction of symptoms Prevention: 1. Killed Vaccine 2. Acellular vaccine a. Contains purified antigens of bacteria b. Given alongwith diphtheria toxoid and tetanus toxoid (DTaP) Treatment: Macrolides