University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

24

Pages:

2
Author:

sonalhava9qv

Bacillus Anthracis and Baccilus Cereus(+) Features: 1. Rods in chains 2. Obligate aerobe 3. Encapsulated a. Protein capsule i. Poly D-glutamate 4. Spore forming 5. Potential biowarfare agent Pathogenesis: 1. Edema Factor (EF) a. Acts as adenylate cyclase b. Increases cAMP c. Causes fluid to move in extracellular fluid (edema) d. Leads to inhibition of host defenses e. Hence, prevents phagocytosis 2. Lethal Factor (LF) a. Kills cells by acting as a protease b. Cleaves MAP kinase i. MAP kinase is a signal transduction protein ii. It is involved in control of cell growth iii. Hence, LF causes tissue necrosis Diseases: 1. Cutaneous anthrax a. Black eschar with erythematous border 2. Pulmonary anthrax (wool sorter’s disease) a. Caused by spores that are inhaled from wool while dealing with it and they germinate in lungs. b. Presents first as non-specific pulmonary symptoms like dry cough, fever etc c. Eventually leads to mediastinal hemorrhagic lymphadenitis i. It presents as widened mediastinum on X ray Treatment: 1. Flouroquinolones 2. Doxycycline Bacillus Cereus (+) Same features as bacillus anthrax. It causes food poisoning (vomiting and diarrhea after eating reheated rice)