University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

72

Pages:

2
Author:

Alexa Livingston

Trypanosoma Brucei Features: 1. Motile with flagella 2. Variable surface glycoprotein coats a. Leads to constant antigenic variation 3. Two important species: a. Trypanosoma Brucei Gambiense b. Trypanosoma Brucei Rhodesiense Transmission: 1. Vector: Tsetse fly 2. Endemic to following areas: a. Western Africa (Trypanosoma Brucei Gambiense) b. Southeastern Africa (Trypanosoma Brucei Rhodesiense) Diseases: Sleeping Sickness Disease 1. Coma 2. Lymphadenopathy a. Cervical lymphadenopathy b. Axillary lymphadenopathy 3. Recurrent fevers a. Due to constant antigenic variation Lab Diagnosis: 1. Trypomastigotes are seen in: a. Blood b. Spinal Fluid c. Lymph nodes Treatment: 1. Melarsoprol a. For CNS infection 2. Suramin a. For peripheral blood infection Life Cycle: (1) Tsetse fly bites, injecting trypomastigotes in blood (5) Replication inside tsetse fly (2) Trypomastigotes moves from blood to lymph nodes and spinal fluid (4) Tsetse fly bites (3) Trypomastigotes replicates in blood, lymph nodes and spinal fluid