University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

475

Pages:

2
Author:

Prince Sampson

HHV-8 Features: Herpes virus family Transmission: 1. Sexual contact 2. Kissing Following have increased risk of Kaposi Sarcoma: 1. AIDS patients 2. Immunocompromised patients 3. Elderly Russian men a. Lower extremity lesions are seen in these men 4. African people a. Virus is endemic in that area Diseases: 1. Kaposi Sarcoma a. This is characterized by erythematous violacious lesions on the nose, extremities and mucous membranes i. May present as: 1. Plaque 2. Patch 3. Macule 4. Nodule ii. Arise from primitive vasculature-forming mesenchymal cells iii. Causes proliferation of vasculature which leads to violacious color 1. This is done when virus causes dysregulation of vascular endothelial growth factor (VEGF) iv. Lesions can also be found within GI tract 1. Most commonly occur on hard palate b. AIDS and immunosuppression are associated with Kaposi Sarcoma 2. Primary Effusion Lymphoma a. It is a B cell lymphoma Kaposi Sarcoma can be confused with Bacillary Angiomatosis. Their points of differentiation are as below:   Kaposi Sarcoma Caused by HHV-8 Microscopic examination shows Kaposi sarcoma accompanied by lymphocytic infiltrate Treatment: HAART is given if patient is HIV positive   Bacillary Angiomatosis Caused by Bartonella henseleae Microscopic examination shows Bacillary Angiomatosis accompanied by Neutrophilic infiltrate