University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

183

Pages:

2
Author:

gewoekerdodx

Chlamydia Features: 1. Obligate intracellular a. Because it can’t produce ATP of its own 2. Poor gram staining a. Giemsa stain needed to be visualized 3. Life cycle consists of two forms: a. Elementary form i. Infectious form ii. Outside the cell b. Reticular form i. Active form that can multiply by binary fission ii. Inside the cell 4. Lack of muramic acid in cell wall 5. Inclusion bodies seen under microscope Lab Diagnosis: Nucleic acid amplification test (NAAT) Diseases: There are three disease causing species of chlamydia: 1. Chlamydia Trachomatis 2. Chlamydophila Pneumoniae 3. Chlamydophila Psittaci Chlamydia Trachomatis: It has several disease causing strains which are:    D-K: STI L1-L3: Lymphogranuloma venereum (LGV) A-C: Blindness 1. D-K: a. b. c. d. e. Most common STI in USA Watery discharge Leads to PID if untreated Neonatal conjunctivitis Neonatal pneumonia i. Cough with short sudden burst 2. L1-L3: a. b. c. d. 3. A-C: a. Causes lymphogranuloma venereum Infection of lymphatics, especially inguinal lymph nodes Starts as painless genital ulcers (like syphilis) Progresses to tender lymphadenopathy with draining lymph nodes Causes Trachoma i. Leading cause of blindness in whole world ii. Transmitted by: 1. Hand-to-eye contact 2. Fomites Other than the above, C. trachomatis also causes Reactive Arthritis. The characteristics are given below: 1. Most commonly affects: a. Sacroiliac joint b. Knee 2. Causes Reiter’s Syndrome, which is characterized by (Can’t see, can’t pee, can’t bend my knee): a. Uveitis b. Urethritis c. Arthritis Chalmydophila Pneumoniae: 1. Pneumonia a. More common in elderly than in adults b. Atypical or walking pneumonia Chlamydophila Psittaci: 1. Pneumonia a. Transmitted by bird droppings (especially parrot’s) Treatment: 1. Macrolides a. Topical application in neonatal conjunctivitis is not effective b. Only oral form effective against trachoma 2. Doxycycline 3. Ceftriaxone (BECAUSE OF CO-INFECTION WITH NEISSERIA)