University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

410

Pages:

1
Author:

folclord7m

Clostridium Tetani (+) Features: 1. Anaerobe 2. Spore-forming Reservoir: 1. Soil 2. Rusted Nails Transmission: 1. Punctured wound/trauma Diseases: It causes spastic paralysis. 2 important diseases are: 1. Risus Sardonicus (evil grin) or Lock Jaw Syndrome 2. Opisthotonus (exaggerated arching of back) Pathogenesis: 1. Spores germinate in tissue and produce tetanus toxin which moves retrograde to CNS 2. Name of toxin is tetanospasmin a. Acts as protease b. Cleaves SNARE protein i. It leads to prevention of exocytosis of neurotransmitters in synapse 1. Neurotransmitters are GABA and glycine a. GABA and glycine are released from Renshaw cells Prevention: 1. Toxoid vaccine a. Conjugated with protein to increase immune response b. It is a vaccine to toxin, not organism.