University:
Eastern Kentucky University
Course:
BIO 273 | Clinical Microbiology
Academic year:

2022
Views:

33

Pages:

2
Author:

Leilani Contreras

Rhabdovirus Features: 1. 2. 3. 4. Enveloped Bullet-shaped virus Helical nucleocapsid Zoonotic virus Transmission: 1. In developing countries: a. Dogs 2. In USA: a. Bats (#1 reservoir) b. Foxes c. Skunks d. Rodents Pathogenesis: 1. Virus has a glycoprotein which binds to nicotinic acetylcholine receptors in post synaptic membrane of NM junction and the virus then replicates 2. Virus then travels in retrograde fashion in peripheral nerves until they reach dorsal root ganglia Diseases: The virus causes: 1. 2. 3. 4. Tingling Muscle spasm Increased salivary production Excruciating spasm in muscles of throat and larynx which leads to: a. Dysphagia b. Foaming of mouth 5. High fever 6. Encephalitis 7. Neuronal death (Symptoms No. 5-6 are seen when the infection spreads to the brain) Lab Diagnosis: 1. Mostly clinical with positive history of exposure is seen 2. Confirmation is done by autopsy or biopsy: a. Negri Bodies are seen in neurons i. These are eosinophilic cytoplasmic inclusions ii. These are found in cytoplasm of: 1. Hippocampus 2. Pyramidal cells 3. Purkinje cells Treatment: 1. Passive immunization with human rabies immunoglobulins Prevention: 1. Active immunization with killed vaccine