Pre-lab Quiz Results You scored 100% by answering 5 out of 5 questions correctly. 1 Cortisol You correctly answered: is a hormone important in the body's response to stress. 2 ACTH You correctly answered: is a tropic hormone that stimulates cortisol release. 3 CRH You correctly answered: has a tropic eﬀect on the anterior pituitary gland. 4 Cushing's syndrome refers to You correctly answered: a hypercortisolism, which could be iatrogenic. 5 A condition of hypocortisolism You correctly answered: refers to low levels of cortisol in the blood. Experiment Results Predict Questions No Predict Questions Stop & Think Questions 1 Normally high levels of cortisol would inhibit release of You correctly answered: both ACTH and CRH. 2 Which hormone(s) stimulate(s) the pituitary gland to release ACTH? You correctly answered: CRH. Experiment Data Patient Cortisol (mcg/dl) High or low ACTH (pg/ml) High or low 1 2.00 Low 18.98 Low 2 34.38 High 12.70 Low 3 43.08 High 90.30 High 4 2.57 Low 104.44 High 5 45.82 High 17.25 Low Table 4.1 Cortisol and ACTH Disorders Cortisol Level Cushing's syndrome (primary hypercortisolism) ACTH Level High Low High Low Cushing's disease (secondary hypercortisolism) High High Addision's disease (primary adrenal insuﬃciency) Low High latrogenic Cushing's syndrome Secondary adrenal insuﬃciency (hypopituitarism) Low Post-lab Quiz Results You scored 100% by answering 6 out of 6 questions correctly. 1 Under normal conditions, if the amount of secreted CRH increases, then You correctly answered: the amount of secreted ACTH will increase. 2 Under normal conditions, if the amount of secreted ACTH increases, then You correctly answered: the amount of secreted CRH will likely decrease. 3 Under normal conditions, if the amount of secreted cortisol increases, then You correctly answered: the amount of secreted ACTH will likely decrease. 4 If a hypersecreting pituitary tumor develops, then an expected outcome is You correctly answered: a diagnosis of Cushing's disease. 5 If a hypersecreting adrenal cortex tumor develops, then an expected outcome is You correctly answered: abnormally low levels of CRH due to negative feedback. Low 6 A patient's chart lists the diagnosis of Addison's disease. Therefore, you expect You correctly answered: abnormally high levels of ACTH. Review Sheet Results 1 Which patient would most likely be diagnosed with Cushing's disease (view Table 4.1 in Experiment Results)? Why? Your answer: Patient 3 would likely be diagnosed with Cushing's disease because there were traces of high cortisol and ACTH levels in the blood stream. 2 Which two patients have hormone levels characteristic of Cushing's syndrome (view Table 4.1 in Experiment Results)? Your answer: Patients 2 and 5 showed traces of Cushing's syndrome. 3 Patient 2 is being treated for rheumatoid arthritis with prednisone. How does this information change the diagnosis (view Table 4.1 in Experiment Results)? Your answer: This would decrease the ability for cortisol to be released when stimulated by ACTH because prednisone reduces the levels of cortisol in the blood by suppressing the function of the adrenal glands. 4 Which patient would most likely be diagnosed with Addison's disease (view Table 4.1 in Experiment Results)? Why? Your answer: Patient 4 is the most likely because their cortisol level is low and ACTH is high which is signs of primary adrenal insuﬃciency.