University:
Tarleton State University
Course:
BIOL 307 | Microbiology
Academic year:

2023
Views:

67

Pages:

2
Author:

Ezekiel Barber

Post Lecture Assignment 4/19 What is meant by selective toxicity? Chemotherapeutic agents should act against the pathogen and not the host. Why are chemotherapeutic agents that work on the peptidoglycan cell wall of bacteria a good choice of drug? Humans and other animal hosts lack peptidoglycan cell walls. Why is polymyxin only used on the skin? It can also damage living human cell membranes, but the drug is safely used on the skin, where the outer layers of cells are dead. Quinolones and fluoroquinolones act against what bacterial target? DNA gyrase Why is it difficult to find good chemotherapeutic agents against viruses? Viruses depend on the host cell's machinery, so it is hard to find a viral target that would leave the host cell unaffected. Widespread antimicrobial drug resistance is usually passed by horizontal gene transfer. Most drug-resistant bacteria isolated from patients contain a(n) R Plasmid Which of the following is a cause of drug-specific resistance in disease-causing organisms? indiscriminate nonmedical use of antimicrobials Which antibiotic is overcome by beta-lactamases? Penicillin How might efflux pumps increase antibiotic resistance in bacteria? Resistant bacteria can have more efflux pumps and can have less specific efflux pumps. Bacteria that are resistant to sulfonamide have enzymes that have a greater affinity for what? PABA Why would an efflux pump for penicillin located on a bacterial cell membrane notbe effective at providing resistance to the drug? Penicillin disrupts the cell wall, which is located outside of the cell membrane. Membrane transport proteins are required for which mode(s) of antibiotic resistance? Efflux pumps, beta-lactamases, and modification of porins all utilize membrane transport proteins. What is meant when a bacterium is said to become "resistant" to an antibiotic? The bacterium is neither killed nor inhibited by the antibiotic. When a patient is treated with antibiotics, __________. the drug will kill or inhibit the growth of all of the sensitive bacterial cells Post Lecture Assignment 4/19 The process of acquiring antibiotic resistance by means of bacteriophage activity is called Transduction Which of the following mutations would not result in antibiotic resistance? Silent Mutation R-plasmids are most likely acquired via Bacterial Conjugation Unlike penicillin, methicillin targets an alternative penicillin binding protein called MecA in nonresistant Staphylococcus aureus. False

Microbiology - Post Lecture Assingment

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