Adrenal Gland - HPA Axis

Adrenal Gland HPA axis mediates (-) Feedback of glucocorticoids Brain HPA Brain (hippocampus) HPA axis (hypothalamus) PVN (hypothalamus) PVN (-) axis ARC ↓ (-) сен ARC CRH Pituitary Gland Pituitary Gland Sympathetic Acute stres LACTH LACTH NS different! (-) Growth Adrenal Cortex Adrenal Cortex Adrenal medulla ↓ ↓ Glucocorticoid Glucocorticald Epinephrine & NE long-loop long-loop Stress axis Not regulated feedback feedback glucocorticoids are responsible for glucose metabolism A. Gross Anatomy 1.30 to deal w/ stress paired, located on top of Kidney! HBA naus deals exclusively w/ chronic stress Captale can be good had for you Cortex Medulla two Systems must communicate wi eachother B. Histology 1. Adrenal Cortex-under control of HPA axis! glandular heterogeneous Steroidogenic produces steroids Secretes -cortisol/corticosterone -aldosterone androgens-weat 2. Adrenal Medulla (chaffin tissue)- under control of SNS Stains w/chramic dyes ne secretion -characteristic of all sympathetic neurons because they produce biogenic amines Secretes Epinephine Nepinephring part of SNS