University:
York University
Course:
SC/BIOL 4320 | Vertebrate Endocrinology
Academic year:

2023
Views:

397

Pages:

2
Author:

Niklas

LECTURE 16: 10/22 I Thyroid Gland FTH metabolism Deiodinase Types. 1) Scheme 1 based an activity how to castify dradinates a.Outer-ring deiodinase 5-deiodinase (5-0) TyTy (biologicalty active farm) b. inner-ring de ladinase 5-de-odinase (5-D) TT ii). Scheme 2 based on enzymes Type 1 (both) in Kidney, and both 5 and 5 Ty and can concert to either b. Type II (activation) has important is ez for negative feuc in begin, placenta 5 only Ts (blalagurally active) CType III (inactivation) brain, stin, pacenta, gut commanly found) Sanly (inactivation) Squamous Low "activity 00 Cuboidal Normal Hctivity" Columnar High "activity" columnar G. Thyroid Bioassays-less Thyroid cell heigh What does it felt us? Tall follicular epithesum indicates high TSH activity Does tull epithelium mean they are producing high TH not really dietary jadide deficiency squamous to low cuboidal colloid cuboidal G. Thyroid Bioassays Dietary Iodide deficiency ex dietary iodide-cennat produce TH Tu/Ts TTSH -epithelial height 7-only 754 levels Columnar apithelial dans not always produce high TSH Any other scenarios shen cotammar epithelium produces low TH? 2 Radiolodide uptake i) Radioisotopes The have sucho tange affer for crets are most efficient splas Porterfomentat Common Cage 1000 high many mazing of incorrect why? mulation Tan functial, Thew will have shart epithelial aimes receptor is broken it is be in small amants mulatiens on NX fpth/TPO gene mutationa Cold nodules hot much activity "Inactive" sites 123 Hot nodules Tco 1231 too much achi tumor indication of radisetapes? De wе пела The process ⅱ) Uptake reflects TSH level NOT TH levels. Shimutates Iuptune Thyroid hormone receptors. How do they produce their effects in target ceta? -TR-RXR binds to TRE plasma membrane receptors (rare) -MAPK activation