University:
Rice University
Course:
BIOS 447 | Biology and Medicine
Academic year:

2021
Views:

316

Pages:

1
Author:

Alex P.

‭Miliary tuberculosis‬ ‭either Bydisseminationgeneralized hematogenous from a visceral focus.‬ ‭Severe: Fever, general malaise.‬ ‭either Umbilicated bluish-red papulesin the center, scattered cold nodules or‬ ‭abscesses (with little inflammation).‬ ‭ ither Course depends on underlying infection. Mantoux -.‬ e ‭Immunocompromised‬ ‭-‬ ‭Tuberculids‬‭:‬ ‭either Injuries fromhypersensitivityto M. tuberculosis with negative culture.‬ ‭M. tuberculosis DNA byPCR. Mantoux +.‬ ‭either Lichen scrofulous: yellowish micropapules on the trunk. Queer.‬ ‭either Papulo-necrotic tuberculides:Recurrent papule-pustules with‬ ‭central necrosis on the extremities.‬ ‭either Nodular vasculitis/erythema induratum (Bazin): Blue nodules on‬ ‭ alves that ulcerate. It is not strange.‬ c ‭-‬ B ‭ CG inoculation (BCGitis)‬‭:‬ ‭ ither Calmette-Guérin bacilli.Mycobacterium bovisattenuated. Papule at the‬ e ‭point‬ ‭either of inoculation that ulcerates and drains. Posterior hypertrophic scar. In‬ ‭immunocompromised patients it could cause disseminated infections.‬ ‭Tuberculosis diagnosis:‬ ‭-‬ ‭If suspected: Mantoux (PPD or intradermorreaction or tuberculin).‬ ‭-‬ ‭Quantiferon –TB and other IGRAs.‬ ‭-‬ ‭Histology: Tuberculoid granulomas, bacilli (Ziehl-Nielsen), caseous necrosis.‬ ‭-‬ ‭Cultivation (Löwenstein).‬ ‭-‬ ‭PCR (polymerase chain reaction). False +. Rule out pulmonary and visceral TB. DD:‬ ‭-‬ ‭Granulomatous diseases with misleading histology. Docrop: Atypical mycobacteria,‬ ‭Leprosy, Syphilis, Deep mycoses, Sarcoidosis, Granulomas due to foreign bodies or‬ ‭Lymphomas.‬ ‭Treatment‬‭:‬ ‭-‬ ‭The same as systemic tuberculosis with three or four drugs 6 or 9‬ ‭months in immunosuppressed patients. Several guidelines:‬