University:
Rice University
Course:
BIOS 447 | Biology and Medicine
Academic year:

2021
Views:

181

Pages:

1
Author:

Alex P.

‭Trophic disorders (sequelae)‬ ‭-‬ ‭Due to neurological alterations, muscle atrophies, scarring and leproreactions‬ ‭-‬ ‭Osteoarticular ankylosis: papal handclaw handfoot drop‬ ‭-‬ ‭Orchitis, sterility, gynecomasti. Optic neuritis and blindness. Septum perforation‬ ‭(saddle). Anhidrosis, alopecia, onychodystrophies, plantar ulcers.‬ ‭Pathological anatomy:‬ ‭-‬ ‭L.I.. Nonspecific infiltrates‬ ‭-‬ ‭L.T.. Infiltrators andtuberculoid granulomasup to the dermoepidermal limit and in‬ ‭-‬ ‭nerves L.L.. Deep Departed (Unna Gang)Virchow cells-foamy histiocytes with‬ ‭abundant bacilli (Fite-Faraco) Abundant degenerated bacilli (globi)‬ ‭-‬ ‭BT-BB-BL.Granulomas and c. by Virchow‬ ‭-‬ ‭LeproreactionType II. Vasculitis.‬ ‭Diagnosis‬‭:‬ ‭Histopathology. Non-cultivable bacillus in vitro.L.L.: Fresh examination of nasal mucus, ear‬ ‭lobe or lymph with Ziehl-Nielsen or Fite.L.T.: Intradermorreaction, lepromin or Mitsuda.PCR.‬ ‭Important to determine clinical type and treatment. Study of family members.‬ ‭Treatment‬‭:‬ ‭-‬ ‭Acute outbreak curable with long treatment.Tracking 4-8years to avoid‬ ‭-‬ r‭ elapses.‬ ‭Need for early treatment to avoid sequelae and permanent deformities.‬ ‭Psychological and social support. Chemoprophylaxis in contacts: Sulfone‬ ‭100mg/d/2 years‬