Toxobase Usage | Lecture Note - Edubirdie

University:
The University Of Western Ontario
Course:
Biology 2290F | Scientific Method in Biology
Academic year:

2022
Views:

407

Pages:

3
Author:

Kyuwon J.

Toxobase usage ● Paracetamol Overdoses ○ Toxic does threshold is given by TOXBASE ■ Adults >150mg/kg ■ Children > 75mg/kg ○ When to take serum level ■ After 4 hr of post-ingestions ○ Nomogram guidance NAC need ■ 4-24 hr ○ NAC regimen ■ Two bag protocols ● 200mg/kg in 4hr ● After that need 100,g/kg withing 16hr ○ Once stop taking NAC early ○ Labs to repeat ■ ALT, INR, Bilirubin, creatine ex) patients ingetsting 20 * 500mg of tablests. Patients weihtgts 60 kg ● 60 ⇒ 166mg/kg (toxic) ○ Draw levels for 4 hours ○ When above treatment line ■ Need to start NAC ○ Check for LFT and coagulation after NAC SSRI overdose ● Typical course ○ Usually mild ● Clinical features ○ Nausea/ vomiting ○ Tachycardia ○ Tremor ○ Serotonin syndrome ■ When large ingestions ● MX ○ Observation on adults for 6hr ○ Observation on children for 12 hr ● Indication when its accelerating ○ Hyperthermia ○ Significant agitation ○ Signs of serotonin syndrome ● When to give crypheptadine ex) patient takes 800mg of sertraline ● TOXBASE RECOMMENATIONS ○ ECG and vitals ○ Observation for 6hr ○ Benzodiazepine if agitation/tremor ○ Discharge ■ Signs of symptomatics

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