Elution Notes | The University Of Western Ontario - Edubirdie

University:
The University Of Western Ontario
Course:
Biology 2290F | Scientific Method in Biology
Academic year:

2022
Views:

44

Pages:

3
Author:

Kyuwon J.

Elutions ● Drug and antibiotic is released from carrier material to nearby environments ○ diffuses or leaches ● Elution kinetics ○ rate of release over time Phase of Elution kinetics ● Initial Burst release ○ rapid at first 24-72 hr ○ drug particles near surface dissolves faster into surrounding mediums ○ need high local concentration ● Sustained / tapering release ○ drug will continue to diffuse out ■ from deeper level of surroundings ■ concentration degrease gradually over weeks ■ rates will depend on multiple factors ● prorsity ● surface area ● carrier types ● Plateau/ Exhaustion phase ○ most accessible drug release ○ release rate slow ○ only 10-20% of total drugs are actually released from PMMA carriers ■ remainder will be trapped in Factors affecting Elutions ● Carrier materials ○ PMMA beads ■ non-resorbable ■ limited release ○ Calcium sulfate ○ collagen carriers ■ resorbable ■ full release once it dissolve ● Drug Characteristics ○ Water solubility, molecular sizes ■ Gentamicin ● small, stable, water-soluble ● elutes well ○ Surface area ■ smaller beads ● larger surface area ● better elutions ○ Mixing + porosity ■ more porous cements ● higher and better release clinical significance ● Dentistry ● Root canal medicaments ● dental filling materials ● prevention on bacterial regrowth in pul chamber ● Tooth model of drug filling = dentine medicament ○ elution into surrounding mediums ● measures release profile ● analogous orthopedic model ○ bone cement beads in fluid vials Advantages Limitations Very high local drug levels Only part of drug released (10–20% in PMMA) Low systemic toxicity Burst release drops quickly Sustained release over weeks Release not uniform or predictable Targets poorly vascular areas PMMA beads need removal (non-resorbable) Can be tailored to specific antibiotics Heat-labile drugs not suitable in PMMA Fills dead space (orthopedics) Risk of bacteria colonizing carrier if left too long Supports systemic therapy Resorbables can cause sterile drainage ○

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