Pain Receptor 1 Lecture 2 | The University Of Western Ontario - Edubirdie

University:
The University Of Western Ontario
Course:
Pathology 3500B | Human Pathology
Academic year:

2023
Views:

241

Pages:

3
Author:

Kyuwon J.

Descending Modulation ● Pain not only is transmitted upwards ● Also modulated downwards (from the brian) ● Inhibitory pathway form brainstem regions ○ Periaqueductal gray ■ In midbrain ■ Central hub for descending pain modulation ■ Initiate suppression in pain signals ○ Medulla ■ Revies input form PAG ■ ON/OFF cells for facilitating inhibition of spinal nociceptive transmissions. ○ Pons ● Neurotransmitters ○ Serotonin ○ Norepinepherine (NE) ○ Endogenous opioids ● Enhance or restrict nociceptive signaling in dorsal horns Central sense ● Persistent input from nociceptor ○ Hyperexcitability of dorsal horn neurons ■ Hyperalgesia ● Increase in response to pain stimuli ■ Allodynia ● Pain by non pain and pain stimuli ● Slight touch for example ■ NMDA receptor is activated = increase in glutamate release = decrease in inhibitory tone ● Primary Somatosensory Cortex ○ S1 ○ Localize + identification of pain intensity ● Secondary Somatosensory Cortex ○ S2 ○ Bilateral sensory input ○ Integration of pain across hemisphere ○ Association of intensity ● Anterior Cingulate Cortex ○ ACC ○ Emotional motivation by pain ○ Insulation focused in anterior portion ■ Interoceptive awareness ■ Emotional experience within pain ● Insular Cortex ○ Awareness ○ Pain linked to body state ● Prefrontal Cortex ○ Evaluation and decision making ○ Anticipating + contextualizing moment of pain Integrated structure = combination fo all relevant brain region Type Somatic pain Origin Skin, muscles, joints Localization Well-localized Often sharp or aching Visceral pain Internal organs Poorly localized Often referred; deep, squeezing, dull

Related Documents

Pain Receptor 1 Lecture 2

Pain Receptor 1 Lecture 2 - Page 1

Pain Receptor 1 Lecture 2 - Page 2

Pain Receptor 1 Lecture 2 - Page 3

of 3

Recommended Documents

IVD Case Study

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Common Prepping Patterns

Common Prepping Patterns

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Dream Disorders

Dream Disorders

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Blood Collection Tube Identifications

Blood Collection Tube Identifications

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Musculoskeletal System Cheat Sheet

Musculoskeletal System Cheat Sheet

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Immunoglobulines IgG-IgD

Immunoglobulines IgG-IgD

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Drugs on Brain

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Week 7 Mid Prep Pectoralis Major

Week 7 Mid Prep Pectoralis Major

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Blood Coating

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Back and Vertebral Column

Back and Vertebral Column

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Patient Positioning

Patient Positioning

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

New Documents from this Course

Transmission Between Veterinary Species

Transmission Between Veterinary Species

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

SARS Global Learning Materials

SARS Global Learning Materials

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Lyme Disease

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Livestocks Study Note

Livestocks Study Note

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Wastewater in China and Netherlands

Wastewater in China and Netherlands

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

South Korean Wastewater Surveillance

South Korean Wastewater Surveillance

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Covid-19 Vaccines

Covid-19 Vaccines

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Clinical Definition of Antibiotic Resistance

Clinical Definition of Antibiotic Resistance

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Loss of Food Source

Loss of Food Source

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

Salmonella Cheat Sheet

Salmonella Cheat Sheet

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

3 Types of Vessels

3 Types of Vessels

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note

History of Vaccine

History of Vaccine

The University Of Western Ontario Pathology 3500B | Human Pathology

Lecture Note