University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

179

Pages:

2
Author:

Niklas

Neutrophils: Regulated Cell Death NETs: Neutrophil Extracellular Traps decondensed chromatin and granular contents Neutrophils make NETs essentially, neutrophils commit suicide when they attack a pathogen → they "spill their guts out" and form NETs in the process Netosis: cell death - characterized by the release of NETs to the extracellular space dead neutrophils = pus Regulation of Inflammation Is too much inflammation a bad thing? yes! sepsis: a systemic response to infection that induces fever, elevated heart rate/breathing rate, low blood pressure, and compromised organ function due to circulatory defects septic shock: Circulatory and respiratory collapse (90% mortality) septicemia: Infections in the blood (example: gram-negative bacteria such as E. coli or Salmonella) Example Situation: leaky capillaries TNF causes endothelial cells to open up this is good when it's localized BUT NOT when it's systemic Septicemia tends to septic shock systemic infections cause blood to move into tissues - not enough left to circulate causes organ failure because there isn't enough blood to carry materials anti-inflammatory cytokines: IL-10 Innate immune response