Immune System Overview

Immune System: an overview what is immunity -immunity: the ability to resist infection by the actions of white blood cells or antibodies -immunology: science of self/non-self discrimination immunology studies everything from macromolecules to organisms macromolecules organelle cell tissue organ organ system→ organism entrance inte body a basic model for immunity: pathogen recognition response anything that causes herm/disease (Keeps organism alive) Who has an immune system? almost everyone/every thing prokaryotes innate restriction/modification enzymes vertebrate innate adeptive: CRISPR/Cas9 adaptive "Though many lay unburied, birds and beasts would not touch them, or died after casting them... The bodies of dying men lay one upon the other... [But] those who had recovered from the disease... lad now no fear for themselves, for the same mais os rever attacked twice never at least fatally invertebrate innate Thucydides, History of the Peloponnesian War, 431-428 BC vaccines and the history of immunology 1st time immunology was recognized() was during the peloponnesion war smallpox on eradicated virus that used to be contagious, disfiguring, and often deadly hypothesized that milk maids who had been exposed to cowpox had built an immunity against smallpox Edward Jenner of ten considered the father of immunology. Funny bacaves he met an immunistegist -given credit for the process of raccination he wasn't the person variolation method of immunizing patients against smallpox by infecting them with the virus from the pustules of patients with a mild form of the disease contacted naturally typically the disease presents in a much less dangerous form then when vaccination - treatment with a vaccine to produce immunity against a disease "vacca" is the prefix for cow variolation vs vaccination ↓ using the actual virus using a similar molecule/protein sequence generates possible generates immunity without inducing disease immunity by inducing w/ disease **How does immunity work?** immunology occurs at multiple levels at the same time Immunity. **Adaptive Immunity** TABLE 1-4 Comparison of innate and adaptive immunity does not react as quickly BUT is stronger andAdaptive Immunityintracellular pathogenshumors fluids in the body