Polynuclear Basophil Educational Materials

‭Polynuclear basophil‬ ‭✪Even less represented than the eosinophil.‬ ‭✪It is clearly identifiable, it is a small cell which co.‬ ‭ There are granulations in the cytoplasm that appear black after staining with MGG, they are very‬ ✪ ‭abundant and partially cover the nucleus which is little or not segmented and which has dense‬ ‭chromatin. These elements come from the hematopoietic bone marrow where they mature, as‬ ‭opposed to mast cells which are elements that resemble them but whose maturation is intra- tissue.‬ ‭ The lifespan of these elements in the circulating blood is a few days. The blood concentration is‬ ✪ ‭<0.1 giga/L.‬ ‭ The mediators:in the specific granulations we find histamine, elastases, leukotrienes, MBP‬ ✪ ‭(medio basic protein of the eosinophil).‬ ‭In nonspecific granulations there are acid phosphatases.‬ ‭Receptors that are important in the basophil: receptors for the FC fragment Ig types E, G, for‬ ‭interleukin 2 and for Stem Cell factor (SCF) which is involved in the maturation of these elements.‬ ‭ Properties :‬‭Hypersensitivity. When a patient is stung‬‭on the liver by wasps, he will produce‬ ✪ ‭immunoglobulin E and during a second contact with the allergens, the IgE which will attach to the‬ ‭basophils will be bridged by the allergen and in presence of calcium we will have release of‬ ‭mediators. These mediators will act on the smooth muscle, the glands (mucus gland), the‬ ‭microcirculation, the mediators promote the local recruitment of polynuclear eosinophils (because‬ ‭this has a receptor for eosinophil chemoattractant factor synthesized by basophil).‬ ‭ When there is action by these mediators‬‭:there is‬‭vasodilation and at the level of the‬ ✪ ‭microcirculation the passage of plasma from the vascular sector to the tissue.‬ ‭ There is bronchoconstriction that is to say reduction in the caliber of the airways and at the same‬ ✪ ‭time it There is an increase in mucus secretion so patients will have breathing difficulties. If there is‬ ‭vasodilation with extravasation of plasma towards the interstitial sector these people will have‬ ‭blood pressure that will drop.‬ ‭ In fact these patients are extremely sensitive and must carry corticosteroids with them if they are‬ ✪ ‭stung and in certain cases if this patient is stung in the upper airways, the life-threatening prognosis‬ ‭can be at stake.So this element is essential for immediate hypersensitivity when there is synthesis of‬ ‭Ig E.‬