Week 7: Cell Signaling

University:
The Pennsylvania State University
Course:
BIOL 230W | Cellular Biology
Academic year:

2023
Views:

148

Pages:

1
Author:

Sarah Landeck

BIOL 230W - Week 7 Cell Signaling — A signal that is sent either from the environment or the cell is called a ligand —> physical signals are detected by receptors, alter shape to make change — Receptors are integral membrane proteins with parts outside the membrane — Components of GPCR = Transmembrane proteins that are integral (7), extracellular ligand-binding region, and G-protein coupled domain that binds to integral membrane proteins — Peptide motifs are strands of amino acids, determined by primary structure Cell Signaling pt 2 — RTK (receptor tyrosine kinase) are integral membrane proteins that phosphorylate tyrosine kinases (which activates the receptor) — Second messengers = cAMP, IP3, DAG, and Calcium (2+) —> cAMP is activated by adenylyl cyclase, and IP3 and DAG are activated by phospholipase C — Kinases add phosphates to proteins, phosphotases remove them