KDIGO - Lecture Note | The University Of Western Ontario - Edubirdie

University:
The University Of Western Ontario
Course:
Pathology 3500B | Human Pathology
Academic year:

2023
Views:

46

Pages:

3
Author:

Kyuwon J.

KDIGO ● Transient AKI ○ GFR returns to normal after insult ○ Pre-renal AKI corrected early ■ Dehydration ■ Hypotensions ○ Mild ATN goes on reverse ○ AKI does not have important nephron loss ○ Incomplete tubular repair ■ Interstitial fibrosis ● Stage 1 ○ More then 0.3mg/dL of serum creatinine ○ Less than 0.5ml/kg/h of urine output for 6-12h ● Stage 2 ○ 2-2.9x baseline of serum creatine level ○ Same level of urine output as stage 1 ● Stage 3 ○ More than 3 times the baseline of creatine ○ 4.0mg/dL dialysis ○ Same level of urine output as stage 1 ■ Or anuria more then 12 h ● Sepsis AKI ○ Renal hypoperfusions ○ Inflammatory cytokines ○ Microvascular dysfunction ○ Mitochondrial injury ● Aki will occur without hypotensions ○ Fluids + source control is significant CI-AKI ● Increase in level of Cr in the term of 48-72hr ○ After iodinated contrast ■ Risk of… ● CKD ● Diabetes ● Dehydrations ● Large contrast volumes ● Concurrent NSAIDs ■ Could be prevented by… ● IV salines ● Lowest contrast doses ● Nephrotoxin avoidance ● Evidence of N-acetylcysteine Rhabdomyolysis ● Myoglobin ⇒tubular toxicity + obstructions ● Clues ○ Muscle pain ○ Dark urines ○ Increase in CK ■ More than 5000IU/L ○ Positive bloods ■ No RBC ● Mx ○ IV fluids ○ Urine output managements ○ Alkalizations

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