Disseminated Intravascular Coagulation | Lecture Note - Edubirdie

University:
The University Of Western Ontario
Course:
Pathology 3500B | Human Pathology
Academic year:

2023
Views:

446

Pages:

3
Author:

Kyuwon J.

Disseminated Intravascular Coagulation ● DIC = disorder with widespread activation of blood clotting system ○ Systemic, all around the body ● Simultaneous clot formation ● Excessive bleeding ● Small blood clotting from vessels ⇒ organ damage Path ● Involvement of abnormal activation of coagulation cascade 1. Triggering coagulation system 2. Widespread of microthrombi a. Small blood vessels 3. Platelets + clotting factors consumed 4. Body system is now unable to clot properly 5. Severe bleeding Could result in both thrombosis + hemorrhage Trigger ● Severe infection ○ ex) ■ Sepsis ■ Meningococcemia ■ Septic shock ● Gram-negative bacteria cause ■ Streptococcal Sepsis ■ Staphylococcal Sepsis ■ Clostridium Perfringens Infection ○ Could also be done through viral infection ■ COVID-19 - in some cases ■ Ebola ■ Dengue Hemorrhagic Fever ■ Severe Influenza Virus can cause systemic inflammation + vascular injury ● Trauma/burn ● Malignancy ○ Leukemia ● Obstetric complication ● Severe transfusion rxn ● Snake bites ● Severe liver disease R ● ● ● ● Severe bacterial infection Surgery (Major) Cancer Pregnancy complications ○ ex) ■ Placental Abruption ■ Amniotic Fluid Embolism Cx ● Symptoms may vary since it both causes blood clotting and bleeding ● Bleeding ○ Excessive bleeding from wound ○ Gum bleed ○ Nosebleed ○ Blood in urine/stool ○ Bruising + petechiae ● Clotting ○ Dysfunction in organ ○ Kidney failure ○ Respiratory distress ○ Reduction on blood flow ⇒ tissue

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