University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

195

Pages:

3
Author:

Niklas

Antibodies, Antigens, and Cytokines -finishing lecture & powerpoint begins on slide 35 Antibody Isotypes: different heavy chains promote different effector functions antibodies have No effector functions, Con neutesize BUT signaling beacon! Antigenic Determinants an immunoglobulins sometimes antibodies are the antigen variable region andigen binding recognition antibodies tecognize other antibodies allall membersthe sum of an individual's allogenic determinants DETERMINESOn Allutypic dera unique amino acid sequence specific for Isotopes: lowest serum levels. Heavy Chain very small BUT powerful IgE mostly found bound to mast cens very polent couse for extstume allergie reachons high serum levels major isotype found in the blood also good at initiating (fixing) complement binds well to Fe receptors on phagocytes apponization is an important function Heavy Chain IgG crosses the placenta Igå antibodies passed fram soon to developing fetus low half-life and serum levels we do not know a lot about IgD Heavy Chain IgD we think it binds to basophilles which aft tate and hard to find IgA dimer combined by J-chain found in mucosal linings/tissues & Heavy Chain nat in the blond gA relevant in vaccines that target viruses found in the nasal/oral canithes Pha/cavid vaccine! molecular weight much heavier because its much larger structure size aids w/ agglutination (chumping). aids in activating complement first isotype secreated pentamer secreated from B-cell during antibody secretion joined by J-chain Antibody Kinetics (of various isotypes) IgM isotope is created first Over the course of time, IgM decreases and IgE increases -IgA and IgE should be shifted down What is meant by 'antibody kinetics'? The time frame in which this is all occuring Antibodies in Children Fetus receives IgG through placenta (bloodstream) baby receives IgA through breast milk (mucosal cavities)