Why MHC Diversity is Important

Why is MHC diversity important? low MNC diversity causes low variance HIGHLY increases the chance that a dusesse could come aung and wife out the whole peputation Wink checlas ormanion devil! -some people are more susceptible to diseases than other people has to do with hous well their MMC molecutes can bind to the antigen genetic bottlenecking a share reduction in the size of a population, limiting the genetic diversity of the species Dean especially in imated poputations because excrnus wirtently the same PH Antigen Presentation: G How does it recogaze and bind Mary different peskin w different molecules? there are only a few amino acids within me peptides that are really important anchor residue Pydrogen boner residue individual amino acid there are only a few residues that are making contact oncher residues HNV amino acids 2.3, and 9 are important Peptides elated hom consistancy between them there is a great deal of MHC class L varlast 1 HN MHC cleos 1 is much more dependent un anchor tesidues thon class 2 Peptides A MHC c H.N NN-COO The Secretory Pathway and Intracellular Trafficking: extracellular vesicles contain some extracellular Fluid space Cyt Golgi NHCI En -0-0-0 MHC ER cell MHC Class 1 MHC Class I Presents Endoganeus Antigen: MHC Class 1 is Symmet vital infection Endogenous inside the cell vitut ontigent are typitany found inases the cell virus infects cells and synthesizes proteins in the cytoplasm } Antigen/MHC class I binding occurs in the endoplasmic reticulum MHC important to present peptide to T-cells T-cells are MHC Restriction -cells will only recognize (foreign) antigen when it is presented by (set) Mic molecules may connot sen tre antigen it could Float right by and it wικά πτην Protein Degradation by the (immuno) Proteasome Cytosol Protein Amino acids Cytosolic protein pool Peptides (Immuno protsasome 195 regulator ATP ADPP Constitutive Immuno prateasome proteasome TAP RER lumen Peptide ready to be 821 loaded ante MHC class 1 molecule ubiquitin marks protein for destruction the (immuno) proteasome "chops up the protein into peptides/amino acids - the proteasame exists at all times BUT in the presence of a virus switches to an immunoproteasame what is the signal for the switch from prole asome to immuno prateasyme? super charged" better of shopping up. FORIEGN proteins interferons! when a cell becomes infected it begins secreating interferons to protect all of the other cells. the original infected cell cannot be saxed BUT it has to be shut down correctly plyptropic effect one cytokine (the interferon) having multiple effects Peptide Transport/Binding rough endoplasmic τα λοίωση Ep57 -ribusemes on the rough ER make MHC class 1 ERAP Cuticle BUT MAG class structure is not stabls on its awm 30 chaperon proteins to mass surs PMHC class I can function MHC class i binds with peptide kicka off chaperan proteina MC meves sut ris secretary pathway 88