University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

468

Pages:

4
Author:

Niklas

Innate Immunity II General Overview of Innate Immunity Three Jobs of the Innate Immune System 1) physical and chemical barriers to infection 2) cellular responses to infection 3) activation of adaptive immune system The Inflammatory Response inflammation cordinated and systemic response to injurious stimuli that involves immune celis, blood vessels and various molecular mediators immune response from an extracellular stimul Hallmarks of inflammation: rubor (tedness) dolor (pain) - calor (heat) -functio laesa (lass of function) tumer (swelling) STEP #1 Tissue damage and bacteria cause resident sentinel cells to release chemo attractants and rasoactive factors that trigger a beal increase in blood flow and capillary permeability -Pathagens trigger a response from seatinal celا what has in happen before sentinal celts least cheme attractanta and vasoactive fachirs? guard cell RECOGNITION Sentinal cells have surface receptors that help to make the correct response pattern recognition receptors (PRR) cach receptor recognises various brood classes of pathogens encoded by the germine ancodes for the central dogma DNA RAP PAMPS and DAMPS: pathogen-associated molecular pattern (PAMP): a common structure/type of molecule thet is shared by a wide variety of pathogens or their components/products large scale patterns that when the sentinal cell sees it, it knows its BAD damage associated melecular pattern (DAMP): a common molecular structure that is produced by a cell when they are damaged/diying csempés Sterile inflammation and ankle Response of PAMP binding to PRR: -ligand binds to receptor stimulation of a receptor •PRR recognizes PAMP cell signaling from cell surface, through cytoplasm, and inte nucleus change in gene expression STEP #2 PAMPPRR interaction results in the release of cytokines and chemokines from sentinel celth/macrophages -PRA are found everywhere Tight now we on tossing of a speciffe cell type Pro-Inflamatory Cytokines and Chemokines ach locally and systemically Cytokines IL-3 liver acute phase proteins activation of complement apumzation bone marrow/ende theliurn neutrophil mobilization phagocytosis TNF- hypa thalamus increased body temperature Its ferers destensed vital and fat/muscle protein and energy mobilization to generate increased body temperature bacteriol teplication chemokines IL- chemeattract cris to infection site. recruits cons from Wood stream to the tissues production of pro-inflammatory ipids such as yrostaglandins produced by activity of COX2 enzyme hibited by nsard (touprofen/Mars) selectiuly inhibiting COX2 and getting rid of the yeo-inflammatory tips