University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

150

Pages:

2
Author:

Niklas

Type 2 Hypersensitivity Transfusion Reaction No-mediated destraction of cets by non-ige Ab Gest 00 Blood group antigens are carbohydrates people possess antibodies against the blood type they do NOT have if an individual receives a transfusion of the wrong' type of blood, their antibadies will quickly attach to the donor blood cells and trigger complement proteins the degraded RBC components can build to toxic levels TABLE 15-4 Penicillin-induced hypersensitivity reactions Type of reaction Antibody or lymphocyte induced Cinical manifestations Hemolytic Anemia IgE Urticaria, systemic anaphylaxis can be drug induced IgM, IgG Hemolytic anemia some drugs can be absorbed nonspecifically to proteins on RBC membranes these drug proteins complexes may stimulate antibody production نوا Serum sickness, glomerulonephritis Tcells Contact dermatitis IV MA Ab bind to RBC's when the drug is present, stimulating complement - mediated destruction Penicillin can induce all 4 types of hypersensitivities under the correct circumstances for each Erythroblastasis Hemolytic disease of the newborn; develops when maternal IgG antibodies specific to the expressed RhD allele cross the placenta (Morm is Rh-negative, develops antibodies against Rh factor/protein in child) Destroys fetal RBCs by binding and activating complement causes child to be anemic as well as a build- up of toxic RBC Can be fatal, but can be treated by intrauterine blood- excharge transfusion and other methods (RhoGAM) Type 3 Hypersensitivity Immune Complexes Immune Complexes a complex of antibody and antigen aka antigen antibody comples mulivalent interactions lead to large, stable structures formed so the immune system can better recognize and eliminate pathogens under certain conditions, these complexes can be harmful because they are bigbly stable, they can depesit in issues & lead to issues like autoimmunity/hypersensitivity Serum sickness Antisarum - TABLE 17-4 Common agents used for passive immunization Disease Agent Black widow spider bite Horse antivenin Botuliam Horse artisan Cytomegalovirus Human polycional Ab Diphtheria Horse antitoxin Hepatitis A and B Pooled human immunoglobulin Measles Pesked human lesuneylobulin Rabies Human ar horse polyclonal As Respiratory disease Monoclonal anti-RSV Snake bite Horse antivenin Telarus Powled human immunoglobulinar Varicella zoster virus horse antitoxin Respiratoгу хулсytta virus. Human polycional Alb CA 1080 Panthodytherspoon progres and contisuing challenges. Cilnicamuning 935