University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

164

Pages:

3
Author:

Niklas

Effector Responses Helper T-cell Review Naïve T cell TCR signaling APCs deliver three kinds of signals to incre Toile ANG NH APC Signal 1 Activation (causing proliferation) Signal 2: Survival w/ signal . the (ти весата виде se apoptotic Gene expression Costimulatory interaction signal 3: Differentiation (nesper T-cell subsets) Autocrine (eg. IL-2) Cytokine signaling Paracrine leg. IL-121 87.1 CD30 87.2 C036 signal 2: Bevis is a mutchanism of perighetul tolerance the presence/absence of signal a helps our immune system differentiate between Foreign antigen and self antigen signal 1 and 2 anly signal! even w/ signals Iand 2. erice it becomes energic it stays anergic Tut twe ↓ 3 APCS dendritic cell macrophage B-cell Co-stimulation what comes then of CD30/84APC demantic st is the APC that con PAMP/PRR interaction on the dendritic cell (APC) leads to 1. the expression of CD18/86 2. the release of polarizing cytokines from the APC the nature of the PAPMP determines which polarizing cytokine is teleased by the ac SILA-4 molecule expressed on the T-cell birok and deerstand Tec COTA molecule expressed on the T-cell MERE ALWATS WINS! "gas pedal" Autocrine Signaling activated T-cells that has nered signals 1 and 2 ars shimmatated to undergo a west of puliteration innillates their ability to begin differentiation proliferative buist is dependent upon the cytokine interleukin 2 (1-1) hindating praferation gune expression of 11-2 is increased w/ signal 1 and 2 moulting in a 100% increase in 11-2 pradushion after T-ces activelion gene expression of - Subunit of receptor la turned on in activated Treells to generate high affinity IL-2 receptor upregulate 12-21 feceptor Naive T cell Activated T cell moderate affinity high affinity IL-2 receptor d-subunit aka 6025 signal 5: PAM binds to TRR on DC PMPpathogen dendritic cell releases polariting cytokines T-cell recognizes cytokines αχριετικά Με bane Regalater STATE TCR effector cytokines αι τελε binds to DNA and impacts the secretion of effector cytosints Mauter () release cytokines JAK-STAT Palhuss CD4 Helper T Call Am 1) palatizing cytokine binds to inceptor brings and legate 2) recepter linnuding Ass) dimerizes and sule phosphorylates 5) JAK yhus phorylates STAT proteins STATA proteins dimerize and localize to the nucices AND promote expression of master gene regulater (MER) 5) expression of Mer hads to caymasion of effector cytokines cytokine subsets