University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

308

Pages:

1
Author:

Niklas

T-Dependent B-cell Responses: B-cells bind antigen via BCR binding induces mitogenic activation and proliferation events induces formation of germinal centers same antigen is internalized and processed presented on cell surface in MHC class 2 molecules Antigen Presentation by B-cell: 1) receptor clustering induces internalization and Ag presentation 2) Ag is processed by MHC class 2 3) peptide fragments are presented in MHC class 2 molecules on surface of B-cell solicits T-cell help Ag Presentation: DC vs B-cell activates CD4+ T-cell same antigen, same cognate T-cell T-cell activates B-cell TFH (T Follicular Helper cells): helper T-cell subset required for the formation of germinal centers AND provide the signals that drive affinity maturation of B-cells Do NOT have to know specific molecules. But DO know what is generally happening! except CD40/CD86 How does a B-cell find its cognate B-cell? CHEMOKINES! bring to the same area :)