University:
York University
Course:
SC/BIOL 3120 | Immunobiology
Academic year:

2023
Views:

256

Pages:

2
Author:

Niklas

Cytotoxic T-cells Antigen recog CD fech Menry Tel Nake T mphoid argens Cre APC Peop CD8+ T-cells Cytotoxic T Lymphocytes CTL Te Cells CDS T-cell response occurs in 2 phases 1) Activation and differentiation of naive CDS T-cells in secondary lymphoid tissues 2) (TLS recognize MHC class I peptide antigen complexes and induces apoptosis at the site of infection/injury Background Information initacellular infections aren't strictly intracellular For example, when a virus causes a host cell to lyse, there will be cellular debris (and virons) in the extracellular environment. That extracellular debris and/or virion (extracellular antigen) is an important signal for the immune system, ALSO CDs randomly migrate from a lymphoid tissue to a lymphoid tissue in a manner very similar to CD4+ Hour dees the immune system fully activais CDs to eliminais infrastihuler microвез улік роботsional mligen pinseating cen happens to be infected CROSS PRESENTATION! cross presentation the ability of one APC to take up process, and present extracellular antigens w/ MHC class I meircules to coat T-cells masily dendritic iztis EXOGENOUS PATHWAY Extracelular becter ENDOGENDUS PATHWAY InrocePelar bateria Intumallation by APC Artigen degradati Antigen degradation Actration of CD4 Th Activation of CDS To General Outline Dendritic Cells (Antigen) 3 Cross-reacion 1) dendritic cells pick up extracellular antigen and present to CD4+ T cells CD8+ T cells COCO CDT colla Full acovsten fand proferson of CD+T 2) T-cell then helps the DC in 2 ways: -CD40/CD40L interaction Cytokine release licensing gives De permission to crass present 5) Crass Presentation DC presents to CDB T-cell cylatoxic T lymphocytes (CTLS): fuiny activated coas T-cell coat is fully activated and can proliferate DC licensing by T cell Dendritic Cell Licensing Ag is processed via exogenous pathway which leads to activation of CD4+ T-cells activated CD4+ T-cell induce co-stimulatory matecute expression in the DC via cylakines licensing allows the oc to present Ag to land activate) CDT+ T-cells Exogenous astiger Dendritic.cell Exogenous pathway MHC clas CDA TCR CD3 Tcell CD40 CD40L A