University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

300

Pages:

2
Author:

Amal J.

Proofreading Mechanism1-ribosome - in prokayotes- -smaller subunitIGSrRNAhas 2criticalIfnot correct the criticalAdenine residuesinteract with bothA residue can recognizeanticodon & codesthe arrival of incorrectnucleotides.tRNAond eliminates theJfanticodon -codantRNA.interaction isConvectproper 165 Aresiduescangetacces toUGCthe nucleotides.AAIncorrectHipout of tRNAGCAA -2) tRNA cannot rotate smoothly (70°- accomadation)if anticodon - codon interaction in not propertRNA in not stable and it will get strain duringrotation and flip out from the complex.xcanttRNArotateHipouthydrolysis of EFTU - GTP to EFTU-GDP and releasefacilitates the next interaction of ribosomes, anticodon-codon interaction should be properfor EG EFTU- GTPto he accessed by FBSGTPFBSFBS has noaccesto GTPGCC,X 11UGC4) Back tracking and frameshift mRNA tunnel has aKink b/w Appsite, it will be ina locked state andback trac king is preventekink in mRNAb/w.P&A.EPA