University:
Swansea University
Course:
PM134 | Microbiology
Academic year:

2023
Views:

116

Pages:

2
Author:

Amal J.

LantibioticsThe torm lantibiotics was introduced as an abbreviation for "lanthionine-containing peptide antibiotics".T Class of polycyclic poptide antibiotics that contain the characteristicsthiother aminoacids lanthionine or methyllanthionine as well as theunsaturated amino acids dehydroalanine and 2-aminoisolactyric acid-Composed of two alanine residues that are crosslinked on theirB carbon of & atoms by a thirether (monosulfide) linkage.lantibiotics are antimicrobial peptides with potential applications as thenex generation of antimicrobials in the food Industry and / or thepharmaceutical industry.Produced by a large no: of gram tve bateria such asStreptococus and Streptomyees to attack other gram the bacteria,and as such they are considered a member of the bacteriains.by one well studied because of the commercial use of thesebacteria in the food Industry for making dairy products Such ascheese. ClassificationType A lantibiotics are long flexible molecules -eg: Nisin,bisin, Subtilin, epidermin, gallidermin.Subgroup AI include mutacin 11Subgroup All include mutacin I and III/TheType B lantibiotics are globular - eg: mersacidis, actagoodineduramyan and annanycin.Typec - Some contain 2 peptides ,eg: halodurainType A lantibiotic kill rapidly by pore formation, type Blantibiotic inhibit Peptidogiyan biosynthusis.->L-lacts NIZORS, 6F3B.Subtilis ATCC663Examples for Type A - - Nisin A, Nisin Z Subtilin, epidermin,L-lactis N8Gallidermen ,Mutacin B.Staphylococus epidTu329Staphylococins gallinarum Tu3928S. mutaniTypeB- Actagardine Lacticin Q 3147B. subtits HILY-850plantaricin C Haloduracin, cinnamycin,Duramycin.Streptoryges cinnarstraptovertillum ssp ssp.Lantibiotic Application.Nisin has successfully been used as a food preservativefor over 40 years ,but its major drawbouk is its limitedstability under neutral and alkaline PH conditions.