Positive and Negative Regulation | Swansea University - Edubirdie

University:
Swansea University
Course:
PM134 | Microbiology
Academic year:

2023
Views:

222

Pages:

2
Author:

Amal J.

SPositive and Negative RegulationThere are two types of regulation of lac operon.Negative Regulation When the expression of the genetic/information is quantitatively decreased by the presence ofspecific regulatory element, it is called as NEGATIVEREGULATIONPositive Regulation :- When the expression of the geneticinformation is quantitatively increased by the presenceof specific regulatory clement, it is called as PositiveRegulationpostine regulationActivat.Negative regulationRepressorNotrascriptionPromote OperatepromoterOperatorNotranscriptionTranscriptionPromoterOperatorpromoter OperatorNo activation)(Noroprossa)Effect of CRP - CAMP on Lac OpenonThe effect of glucose is mediated by CAMP, as a coautiateand ant activator protein known as CAMP receptor proteinor CRP (the protein is Sometimes called CAP for catalon gene activator proten).CRP is a homodimer with binding sites for DNA and CAMPWhen glucose is absent, CRP P-CAMP binds to a site near thelac promoter and stimulates RNA transcription 50-fold.CRP- - CAMP is therefore a positive regulatory element responsiveto glucose levels.low [GIC]Adenylatehigh (GietcyclaseATPAdenylateCAMPagranATPCAMP.CAPPlPRNA polRNApol.Functions of Component of Lac OperonAn openor primarily consists of two elements (genera) Regulatory clementsb) Structural elements.

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