University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

325

Pages:

4
Author:

Amal J.

ORC Corigin Recognition [ATPase complex) associat withraises celletaG1 phaseIAAA ATPActivies)PeeintiationJanicyORCH cdgtedt1 + MCM2 7complex (PEC(2 in a headtoCdC6helps to recruite belicasehead fasticdts2 MCM 2-7 CheteohexamerMCM-minicin head to head fasbion in ds Dehromosomalmaintenanceone morve as the top laggingstrond and th en on the bottom ladStrandAllorigins got liscenced in G1 phaseKinase activity in G1 phase allcomponent in PECare in dephosphorglatedcondition.2 Gi/ Ss transition2kinaseactivals)DDKCDK(DBFdepententrsIph71a)(b)1SH2P10Sld3MCM 2-7Cn2biodsrecruite3birdP3+CGINSppbllCLCUBG4CMG complexactivationof helicasenotesORG-In the intial state of Gjphase ORC CAAA ATPase)CDGE and CDt.1 helps to recruite MCMS 2-7helicase[ hetrohexamer] These factors are calledlicensing factors and now it in calledpre-intiation complexGills transition occurs two 2 kinases aleactivatedDDK4CDKDDK phosphorylatesDBf4dependent kisareMCM 2- of fulicase81d2 f 8(0/3Phos Plorylate dSbd21sld3 resuites Dpb 11 which requite now it is calledeMGcomplex activating MCM27.helicase.Initially MCM2-7 recruited ain head head tohead fashi onio Ds DNA ,after activation 2 helicasemove in two opposite direction through the largeyingstrant.265(UD)ProteasomecomplexOb76aminoa protein.Protein destructionsippal.masked by dephosphorylationI(obta.Proteasomkinaserbythedestructprotein + (ub)n recycled backDE/DDK: CDC6 & cdt1 after CMGformation 80 thatonseintiation in prevented.DeportianucleusPC Dt11250/ CDC30E3orMC09/4GeminindenstronikeMphuPPrevent reintiate23asus... collision & depber PhoryanCyfoplanCDC6CDt1RemoveE3 DeganeAPEOdetachExportCOCIHG[APCCBHtin MphaseGreeremavedPhosphalase27removal50% CDCE& CPt1 inM 50% Be improvementHow entaryotic cell ensures replication occurs onceper cell cycle?CDK phosphorylate CDC f CDt1 ) 50% of thephesphorylated 50% proteins binds targeted to proteasomal destruction,remaining with Geminin.transported to cyterol ((exportio)Activate helicase collide and seperate from the DNAin reintiation of thene factor process.These 2 events helpsWhen Cell enters last stage of Mphase on-E3uhiquitin ligase destroy Geminin (hyubiquitination)Phospbatase CCDC14 phosphatase) remove PeDC to rebuid , CDt1 and helicase these factor groupson readyto origin.Peimer25N & of oniocannot--EcleavemeltingRNaselt orDNA&FEN (flapokazakia - -100-200in eukremoveRNA-ONSAEndonoclean)JunckPeimerremovaland continueremoval uptofimutaneasliguse seals nickS/E polymerremoval in of minor firstatchDNA sinceATP in source of activation inwkaufotes.a which lackssynthesised byaspNAnuckercesprofread