University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

473

Pages:

3
Author:

Amal J.

InhibitorsReplication of Peokayotes:1. Novobiacin2. Nolidixic acidInhibits Topoisomerase II [Gyrase]acin3. CyproflaxiaseReplication of Eutacyotes.1. Camp tathicenInbibits human topoisomeasel [anticare]2. AphidicotinInhibits euk polymerase. [Fongalderived]3. Doxorobicin4. EctopesideInbibit Eukasyotic Topoisomerase I5. ElipticinProkaryotic TranscriptionI1. RijamyainAntibiotic2. Ryjampicinsynthetic delivativeof rijamycin3. sorangich4. Streptolydigen Eukaryofic transcriptionNucleousRNA Pol - -I - YRNA nucleolus (185,5.89285) 55 outside nucleolos, remaining inRNA Pol - II - (Allprotein coding gones) hrRNA(exont inton)NA Pol - III - miRNA, tRNA, splicioromal R(JA (exceptus) mRNAJ, SiRNA,ERNaseH, FSL 5.5 SrRNA, U6, RNApalt of RNaseRNA (Part 8/SRP) P,TEFBSieRNA -induce cleavage of comple mRNA,kisasemiRNA - inhibit translation by binding comple MRNASpliciorome -NNP, RNA rich with Oridine- - U [02-U7)ribonucleoproteins.SRP- signal recog Particle Chodishchap 13)L-amanitin (Amanita phollodes) Phalloidin_ - Inbibit actinpolymerisationInsensitive - IHighly sensitive -IIslig fifty sensitive (1000times - -IIImarconcthan II)actinomyain - D Conticance)- Transcription inhibitor ofboth prok & euk- Intercalating agent,b/w GC rich regionI - highly sensitiveII2&stightly sensitive.III 3euk pdymel as have the is poyyptiaes from ProkRNAPOLI - IH - subunits. Rpa - -14RNAPol II 12 subunits, Rpb 1-12RNAPolIII - 1780hunits, RPC14BBa( Rpb 1, Rphz, Rph3)largestpolypeptide in RNApolIPlants poccesCore PromotersTATA box - -25/-30RNARNAPolIVPolVmiRNA.