Internal Ribosomal Entry Sites (IRES) - Edubirdie

University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

264

Pages:

2
Author:

Amal J.

Internal Ribosomal Entry Sites (IRES)connetA&E,mRNA seacirculalizeVirus inject genetic material into cellMRNAHijack the cell machieneriesutilize translational of bosthalt host translationandUse machienelies for theirtranslationPolio virusViral proteasecleaveCIF4G NterminusNP100virusP100 interactbostwith IRES intranslationvives andblocked facilitate bindingof ribromes.Hepetitis virus CeIF4 notcleavedIRES directly interact with EIF3. andcan promote binding of ribosome. Hepetitis ADirectly interact with 40s ribosomeCricket Paralysis virusIRES form InrtRNA minicing structure andstart stranslation.In EukApoptotic proteins have IRES.reduction of all functions @ apoptosistranslation of Apoptotic proteinApoptotic GenemRNAIRESProtease cleave eIF4-E.interactwith + sibosomeand translatestop normal mRNA'sXtranslation.translation inhibitors- - -Read Pg

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