University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

111

Pages:

5
Author:

Amal J.

-Spontaneous Mutation (strond slippage can abscause spontoners mutation(1) Tautomerism -Tautomeric shiftAll base exist in common and rare form.commonrareA&Camino formmino formNH2@topformedopeinghyrolon shift.G&TKetoe nol form AminoNH2NHI11CCN11NNH-NCIACA11CHCHCC/INNHC INNaminoiminoItNH2NH\C11CNCHIHNCHcCourCHNoffCHNIaminoiminoKetoEnolO11OHHNCINCNICN\G11CHNCCCIGCuNNc-/HCINNItKetoemol6OHC1HNNC-CH3IT\TCo"NKetoOofN-HH enol A C of G TGCATTransition11end1111GCGTGC + AT|11Transitiontatomeuism leadsto transition1111A CiminoAAT11Incorporationerror1111SGCreplicateGTreplicationGCAITreplication1111errorincorporatedpolymelaseG Cerror.cannot disfinguirbif it's normal/mutated. 2) Deamination - reversible, leads to transitionexocyclic amino group!A, C G.,DNA in aqueous6thtb2ndmedion.CCCNH2H2ONNHNANNNNHHAdeninehypoxanthin11CytosineGuoninineXanthin = ThymineCytosineUracil5methyl cytosineThymineC1GCdeaminationGOof C11A2TransitionATA(GCAT)( GCTA)Transversion) /3H2deaminationATof A 10HHTHC3HC144GCsamesam.transition124&transitiontransitionreversible3) DeporinationBreakage of purinesPycimidineBase to sugarN1. glycosidic bondNa glycosidic bonddepyramidinationPPapyramidicicAsiteSugardepurinationSugaraporisicsite/APsitePPGGsugarEnga