University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

392

Pages:

4
Author:

Amal J.

Different Hox genes specify different structures.determine limbfieldI cells from lateral mesodeem moveto 4position with help of HoxLimbThis become skeletal structureoffieldNlimb.(4)2 somitescontributes to muscle cells.groopof cells migrate to limb fieldwhich becomes muscle cells.Lateral mesoderm + SomitesLimb fielddevelopmentInitially Lf in having harmonious equipotent groupof cells - they have ability to 100 produce individual limts whenseperated5050malasbothgroupdevelopjully developedlimits. Frogs in America more than Alimtsbcs of Parasite the evade Lf during limbdevelopment & split Lfinto2 armore.TrematodeParasite.frog in an intermediate host of the wardsfrog can't hope propaly doeto extrailimb. (hindlimb).defenitive hort baonenter the bird's body &completefrog incruught bybelon palasitesit's lifecyclesometes.Surfaceboxgene concentrationectodermTbxTbxgene(differentset ofgenesHoxgenbased on Tbxgeneconactivation forelimbd bindlimbLateraldevelops from limbfied.VecterralPlatecolumn(mice)MexotamTbx 5Tbx4 + Pitex 1 & Islets 1(Pitx IfForelimbhindlimb.imp forhindurbdevelopmentFGF10 TbxHoxTbx genefirroblast Growth facTbx 5Tbx A*fGF(forelimb)(hindlimb)(10)*PGF 10mesadersprov. ?+ve(helps in proliferation of mesa feedbackFGF8 * cFGF 10Mil NON :on. wnt signallingpathway.in th surface ectodermfGf8in surfaceActivate / Produceectodermdiffosed stimulateproduction of more FGF 10 fromlateralplate mesodermThis in like apositive feeldback loop. Chappens throughoutlinmore & more dellget prolijerated and Limbfiedpusbed outThisforms the Limb bud. Actively dividing mesodem Mesenchymalcells.Progress zone 1 Proliferatingin mesenchymalcell)Produce fgf10mostdistalregion of surfaceectodorm modinco faff