University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

256

Pages:

4
Author:

Amal J.

5Inter Digital Mesenchyme (IDM)uIf web removedIDMBMP present(IDM)2Determines specificity3 (becomesof each digit (stspecifiesthe digitabret2nd)removed IDM.bw3th.4Digit Identity lost.5NogginBMPIntroduce noggin @ IDMEMILY1BMPDigit Identity lostBMPconc also helps in recruiting mesenchyinehigher conclargefingerdigitidentitylower concsmall jinger. How 3bb identify the digits:-S Bbbfirst act as morphogens that give identityto each and every digitItact as a mitogen (moleules that helps inmitesis) helps in proliferation of mesenchymal cellsShbhas targetgones (regulated hyGli3)Glisregulate 3gene products.CDKGGremblinHyaluronic Acid (HA)1 @(Hyaluronic acid synthane [HAS2] 2)BMPBMPregulatorcell@ condensationadhesionBone morphogoneticBMPmoleculeProteinFirst formed cellsCholds 2 cells together).Controcytes ( Precursor ofcartilage)Prevent skeletal damage ,ectremetips of skelelon is made of catr.mesenchymal cellsaProliferation mesenchymaltransformscells alftoo cells are neededfor production of humoreshControcytes100 cells comprels3 stepseligiachondiocytes.ProliferationcondensationBone formationBMP:BMP)CDK64GDKGHA(HAS24) obi del willHemimelic extra toe - condition in mice atcats3)extra digits @ anterior endThumb in idependent toward anterior to Zonic region Hedgehod, ZHh in inhibitedby binding silencers an enchances region.in case of heminelic extratoe single base pair motation@enchancer region prevent the binding any repressorsand 3hh impresent @ anterior end.Hrithik RoshinPoly Dactylus condition Phenotype inhoman.Zonic Hb acts in 2mannescellsthatcells thatproduce 2Hhreceive ZHhDigit 1 no Zbh.Digit 2 dependent on diffusion zhh. Znocellsthat produce4Digit 3 Teis notificells produce 2hbbrood9higher Zhbin 5 than 4 concytimeDigits 4&5highsonic hedge bag, time Iof expreision of way high. Digit 5has more conc& time than 4 MeisStylopodHoxllZeogopodcopi of the gene products indifferent indifferently agedHox13Autopodmesenchymes ondembdevelopment independenton mesen chyme.Anterior. - Postaion ascisZone of Polarizing activity (ZPA)Particular groupof cells in future posterioraside dox to body asicsSCompound @ ZPA onic Hedgebog(sbb)expt ZPAafisturie anteiliongrafted ZPA leadsto duplicationof perteiiorstructuresin theanterior slidemirror image.APostelior DuplicationTATTEEmirrorasts(Fixoti)imageelece[iixott)