University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

49

Pages:

3
Author:

Amal J.

careInternal Fertilization in Mammals :-Isthumus (capacitation)FemaleAmpulla (fertilizationIcapacitationstaysCapUterusmoX't specificallyInfandibulamGreenutering stractionegs3eggwhenFimbriae (catching2specialovulated egg[.2 uterineovary&musclecontractenablingsparntoCervixreach1sperm trovesby tail movementYchfalopion fumVaginal regionPromiscuis mating1 female - different males at rapidCsuccessionspeinfrom same mate comecloses anIformspein trainIncreases motilityhwhen they are inmale speinscontact, more speines,faster swimming1are competingfor fertilizationSperm RheotaxisThe speim are able to sense differentcapjons, i moving fromyalopian tube to uterus abdmove towards high ionic concen trationDPH dile and Mrs carcum sensitycarsperJchannelfrom vaginal tubeSeaurchinCapacitation - Process by which spain undergo differe.modification so that they are able to fertilize theegg happens @ isthmusveryfastproviding & ensures.processcontinous pelm supply towards ampulla regionYchromorome containing - speedy sperms- moves very fast and skipscapacitation and unablethe egg.Capacitation.moving from vagina. to utewsbash envspainhead covered with fats and carbohydiatesProtectcellmembrane and useful receptors.s,1Sesam Albumin Protein @ jalopian tobeJtremove(chrtestrol Acceptor).cholestrolTransient binding b/w isthmus and spelm beforecapacitation- Isthumus produce fibronectin- Sperm has integuin + bind transiently Most of the receptons and channels are concentratein the lipid raft, when cholestrol in removed and the lipidraft binds to the tip of speim exposing receptors, it canbindeasily to oocyte PMCarbohydrated Proteinremoval - Expose channels and receptors.Membrone I Potential changes.gitbeinbicashonate H3CO32channelKtserum300000alhuminremoval proteinca2+of cholestroHCO3K+2Iopening-vepotentialof ca2 +IncreasedChanelPypin activity(membprotein)moreActivation ofSACYSpeim Adenily cyclase)ATPATPCAMPhyperactivated (capacitatedspeimHyperactivationPKAof spermsPhosphorylation of lyeonine kinasedetachfromisthumexiborn amounted -rispatri worl -