University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

276

Pages:

3
Author:

Amal J.

Epiphyseal Growth Plane (imp for bone growth)( growing region of bone)high proliferation of chandiocytesAfter birth there are cells in bone that act as poolof stem cells for chandiocytesthen replaced by osteocytes..Tpregion of bone EGPchondcocyte osteocytesEGP @ poberty moltiply @ faster rate due tohormones.EGP dosed at a particular time, when EGP isno longer active.hDwayism (arandioplasia)short statured, EGP closed prematerely(Fgf R3)receptors in proliferating chonderitysFgftsGujreplaced by Argmutated continous4@transmembFgtR3portionactivity evenin absenceof ligendEGP closes in afaster rate. mutation @ extracellu lal portion/Tyrosine Kinasedomaisin cytestic domain.Thananthophoric dysplasia [letbal]Affect development of long bonessibragesib can't support lingsBreathing problem, foets dies.eg:- Dashshunt dogs (Premature dosage) recepto extra copy early. of EGF fgf4 closesGrowth hormoneshelp in bone development.GHbinds to receptor in liverInsolin Like Growth factor (IGF 1)slimutatechandiscyfes proliferationAfrican pigmieshave less noiof growthhorinones in liverGrowthretaidation. inEstrogen (imp role in closure of EGP)males basetestatelonefemaleshaveAromataseestrogenconverted toestrogenIn care of gigantismmutation @ Aromatase inmaleIn most casemales are affectednoestrogenby gigantismno EGPclosurecontinue togeowGigantiem.Eye Development2 group of cells which can indoceeye developmentInducerResponder.Produce a signal (inductive Inductionsignal)receive competent inductive tosignal.eyedevelopment