University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

101

Pages:

6
Author:

Amal J.

Clasical Example ofreceprocal inductionInducesGivesRespondersignalreceivesitsignalshoulApointsignalBB1Sippleget specifiedgetspecifiedA1BA2telencephalonanteriarforetrainbraindianceptatormid brainmesian cephalonhid brain.metan ce phalongleposteriorman cephalonspinalcorddiancephalonneurabal part of eyeanterior, ectodermlens. gastrulationin RetiraPeecodalforegotfrom anteriorneural tubeEndodermPlateEndodeemThese 2 cellsicontribute agroupofcellsmoleculePax6 toactr anterior ectoderm.diancepbalonenlargement ofdiancephalonAnterior ectodermlensplacodesPax6Anterior neural tubeParkGlocal thickening IT @ anteriorirectodermAnteiior ectodermal Placodes(Development of sense organs)0orAoticDollactorylensplacodesplacodesplacodes Eyefielddeveloped in anterior neural tube (ANT)@diancepbalonParc 6 concentrationnogginthrough pathwayEyefiel@ANT@diancip1EarlybalonBMPTransaipt(ET)Otx 2firstgroupactive ineyedevelopmeOtx 2 highi (when otx highnoggin)hogginLETETRetinal homesboxshow!ustagone (Rx1)-Pax6nowanteriorweRx 1havetoneuralOtx2stoptobe R of diancephalon1activity ofEtET Shh (splitseye field in to 2)Condition called Cyclopiamutation in shincannot split eyeigheldin 2single eye belownose.Sbb + cholestrolmodified move throughPMblockmotationmovement11of synthessCleave Pax6Cave dwelling fish, shh Cleave whole Par's (no eye).higharalsensingactivity & lauger Jawsurface dwelling fish8bhcnorm)cleavage of Pax6normal Rx1Pax 6NicamcytosteletalproteinEvaginationof eyesfieldvesiclelike structurecalled optic vesiclegrow & touchanterior ectodermhosphouseshouldflattens& produce3-moleculeBMP4 Detta2fgf8formationsflens placodelensplacodegives signal back to optic vesicle (fg(s)get specifiedintoopticcopx mesenchym al cell(2VSSC2VSXImesenchymalcellPgfdsactivationmitfgenof vsx2genemitfgenePigmentedmelanin pigmentretina.neuralretinaPigmented refin501Pigmented retinisnevral retinagives signal to lens placodelensplacode invagination into optical cupforms lens vesiclelensvesiclePinching off of lens vesicle4