Coordination of Three Axes in Limb Development - Edubirdie

University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

164

Pages:

2
Author:

Amal J.

Cordination of BaxesProliferation & ceasing of limb development joetalstage@fgfiofgf8GremlinSbb BMPAER,Sbb fgf +ve loop (Growth)AER fgfShbGremlinBMPfgf 4,9, 17lowfgdSbb fgf - ve loop (fgf gremlin loop) (condensation)A'ER,fgfGremlinBMPTcondensation.highfyfinThis takes place upto Gremlincanot reaches AERa particular time point BMP@AER. decrease fgf& AER cant further develop @ foetal stage limb developceases cou sation of jointsa particular BKTccalledGDF5active@regions. were jointshas to be formedGDF5a particular region aftercondensationBrachipodiamotation of GDF5; lack of limb jointsnecrotic zones(Apopteris ocurs)(1) Inter digital(2) Interior necroticmeroticzonezone(3) Anterior& Posteriorzone in between b/w radiostherotic zonedigits.UlnaShapes ourfingers -Default fate of BMP.BMPFGF (AER)DKK -1)**4(helper)Cartilages.(Dickkopf)WntApoptosisfBcatanein(ensore apoptosis)

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