University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

269

Pages:

3
Author:

Amal J.

Cotranslational translocationSRP2SRP2signalNH!++ sequenceGDP+PSRPreceptorCytosolGTP(PSH)2GTPGDP+P(B)GTPERmemb(a)ERlumonClosedTranslannsignalpeptidonecleavedtranslovon.opensignalSequm6proteinpulledin byfoldedprotein.GThydrolysis ofEF2-GTPSRP.tronslochhchannelNihonocleoproteinSec 61 complexmammalian Sec6l (3 subunit)RNAProtein partSecGId Sec61B7SLRNA6 sobunits300nucleotide(1) P5fsrhonit - Gmokinporeof-interactswitttheN-terminos signaltransloconsequence.lomemtronespanning domain chydrophobicaoe)Chaperons Dolicol pyrophosphateBan. BacitracinInhibitsDolical phosphateblocked by tonicamycin- structural analogue ofdolicolaN-AGInasUPPUDPcyloolUMP5GDP-049005GDP3UDP 300P-UDPHipglipPoKHipwomen.- -Nacetyl Glocosamine -6-Mannoseh- -Glucose 3cytoolNglycosglationTo cis3go(GBcosegolgi(Man)aremoved(Man) 8 (GICNac),(Glc Nac)in3sters13 Protein Disoffide Isomease - Catalyse disolfide bond formationin Eklumen(PDI)(a) Formation of disolficle bondSHcysteinePDIalso has S.reducedS=S oxidizedPDIform S=formEVOToxidizedreducedSHDDI 11SItSHSHSHS=S(b) Rearrangement of dirolfide bond--PDI helps in reauangement of S=S for properSHconfirmation acheivingReducedSHSHPDISH10S=SSS=5incorrectcorrectS=SS=Sbondbond.2.?Anfinson's expt t Leventhal Paradox)Rihonocleone enzyme activity studied - -Peope"Bmercaploethand (dirrupt S=S bond)8molar Urea (dissu pt hydrophonic interaction)n Lannd