University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

424

Pages:

4
Author:

Amal J.

Cyloroticpathway- Proteins are delivered to target except mtfebloroplastin teractions.- Disolfide bond formati on by hydrophobic Pancreatic Bcell enzy2different types of Protein (caigo)Glycoproteins stored invedeliver contant to deodsBcell-Insolinmembronesolublecargocargo- membrone- not memtrone boundbound.Soluble cargoGlycorglationAddition of carbohydrate moletyfor stability of proteins.Protectionfrom degradation byproteases in blood/once they arerecreatedoutsugars are bulky groops, when they are present proteases will noget access to aa- -Exptglycoxylated & non glycosylated firronectinmorestableAct as signals for targetingMannose 6- - P in the addies for lysocmescell to cell adhesion, sugars on protein caninteract (act as receptors) 2 different types of glycosylationSugars added toAsp X - Ser/ThrNglycoxylationO-glycosylation(E.R)(Golgi)amino groupofOH group ofSes Thr.Asn glycosylaleyloligoracchprecursor- sugar added to the peptideUDPthigh energy)(GICNA), (Man) (GW)NacetylGDPglucosalninecabohydiates in cytool, peptide in ER lomen.has to transportedto ERDolichol-Phosphate (highly hydco photic, in E.R.)Pa(caneasily flip to cytosols ER tumen.75-95 carbonDot-PUDP- G/C NaUMP()Dol-Pyrophosphate - GlcNaDol--PUDP - G/C NaUDPDolP5GDP -(Man)GDPDol- -PP(jliptowmen) new dol -P4 GDPmannose4 IDPadd 4 mannosephosphatidyl Binsositol & winonew dolPcornical3UDP- glocosecytostic&Cblood group - glycoproteinsinextracellite3UDP.elythrocytementadd 3 glocose0 - GWC- Gal - Naegluc- - Gal clesficoseB - GLOC - Gal - Nact. - Gal - Gal (Foreign to o)IA- - GW - -Gal - Nac Gal fuc - NactGalFuc.