University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

360

Pages:

2
Author:

Amal J.

Post translational IronslocationADReATPond contractor Aor- rigour martis-bappens in yeastfor muscle relaxation- Sec 63complex heal Sec61sec63a.hydrolyse ATP onBip ATPBip ADP- -bindsproteinsBip chapecons inside E.R women, found bound to protein in ADPform , BipADP prevents backtracking of proteinto cylosolanationalsignal directthe peptiditoER1cytool23ERlomen Sec63CleavedAtANSPiPrevent misfoldingsignalbacktracking.Chapewnsequance BipATPase.ATP&AIPSCplADPExpt - Polse chase expt.George Pallade f Plobel - Nobel prize for recreatory pathwayCells that are sereatoryrich in cough E.RAcinalSelected pancreatic ciscanal cellradiolabelled aa intocellincorporated into newly formed proteinsobserved radio labelled aaERenter lumen of E.RhomogenizedmicrosomesAll.5SecretarydeteigentsnondetergentProteins Enteralter permeabilitytreated microsomes at different time internal totranslation machiemaryadddonotfully translated protein + microsomeProteins enteradd.during translation of pepticle + microomeProteinsdonet entermicrosomes.Peptides enter contronsationaly +Rabelledsecreatoryprotein.&Treatwithdelag entDoAddproteouseAdd prokaseRonodegradationDigestionof secreatoryof secreatoryproteinproteinJ.